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LC-DERIVED EXCITATORY SYNAPTIC TRANSMISSION TO DORSAL RAPHE SEROTONIN NEURONS IS INHIBITED BY ACTIVATION OF ALPHA2-ADRENERGIC RECEPTORS

The dorsal raphe is innervated by noradrenaline neurons, which through the release of noradrenaline causes the serotonin neurons to fire action potentials

 

But where are the noradrenaline neurons projecting from and how is noradrenaline release regulated?

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POTENTIATION OF NEURONAL ACTIVITY BY TONIC GLUD1 CURRENT IN BRAIN SLICES

In cell lines and brain slices, GluD1 and GluD2 receptors are open in the presumed absence of agonists and carry a tonic current.

 

But what allows them to be open?

SPATIOTEMPORAL CONTROL OF NORADRENALINE-DEPENDENT SYNAPTIC TRANSMISSION

Activation of 𝛼1-adrenergic receptors by afferent-derived noradrenaline produces a synaptic current at persists for tens of seconds.

 

Does this reflect the lifetime of extracellular noradrenaline?

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IONIC CURRENT CARRIED BY DELTA GLUTAMATE RECEPTOR-CHANNELS EXCITES
DORSAL RAPHE NEURONS

Activation of Gq-coupled 𝛼1-adrenergic receptors drives action potential firing in serotonin neurons.

 

But what channel carries the current?

Read the article in eLife

Or check out the eLife digest - "Channeling the positive"

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