SPATIOTEMPORAL CONTROL OF NORADRENALINE-DEPENDENT SYNAPTIC TRANSMISSION
Activation of 𝛼1-adrenergic receptors by afferent-derived noradrenaline produces a synaptic current at persists for tens of seconds.
Does this reflect the lifetime of extracellular noradrenaline?
IONIC CURRENT CARRIED BY DELTA GLUTAMATE RECEPTOR-CHANNELS EXCITES
DORSAL RAPHE NEURONS
Activation of Gq-coupled 𝛼1-adrenergic receptors drives action potential firing in serotonin neurons.
But what channel carries the current?
DIRECT ACTION OF THE ENDOCANNABINOID 2-AG ON A-TYPE K+ CHANNELS
Endocannabinoids are lipid-signaling molecules mobilized by activation of GqPCRs.
Membrane lipids are known to act directly on ion channels, but do endocannabiniods?